The area should go white; remove the pressure and the area should return to red, pink or darkened color within a few seconds, indicating good blood fl ow. x�b``�```Ua`c`��ad@ AV�(���@��X@�Lc�Ƨ3W� H�dTMoS1��_����ݵ�MR����8= 0000011177 00000 n Test your skin with the blanching test: Press on the red, pink or darkened area with your fi nger. 1989;125(11):1558–1561. Blanching of the skin causes the skin to appear white or paler than usual, depending on your skin tone. 0 0000003679 00000 n While the precise mechanism of action is unknown, the observed pharmacodynamic response is the blanching effect. 0000110665 00000 n The blanching effect has been used as a measure of the percutaneous "absorption" or "potency" of glucocorticoids from topical formulations and has been used in evaluating and selecting optimum formulations. [sup][9],[10] All the cases which appeared dark or brownish under VELscope were subjected to, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Comparative study on the efficacy of tissue autofluorescence (visually enhanced lesion scope) and toluidine blue as a screening method in oral potentially malignant and malignant lesions, Blanchard Valley Academy of Massage Therapy, Blanchard Valley Paranormal Investigation. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. `Vasoconstriction'—Skin Blanching—Assay for Glucocorticoids—a Critique. 0000110590 00000 n 0000054736 00000 n 0000009443 00000 n 0000005735 00000 n Topically applied glucocorticoids (corticosteroids) elicit a pharmacologic activity (blanching) viewed by many as being "vasoconstrictive" in nature.

Dysplastic tissues with significant keratinization (leukoplakia) can exhibit increased whiteness with loss of fluorescence (darkness) around the periphery of the lesion. 0000010377 00000 n 0000054885 00000 n

Failure to do so suggests impaired blood flow to the extremity. 16 47

While the array of causes can range from trivial to severe, it is believed that the condition is primarily visible in medical emergencies or can be caused because of temporary reasons. to download free article PDFs, From the Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Md. Get free access to newly published articles. 0000008688 00000 n atrophic elderly or sun damaged skin or a coagulation disorder

<]>> 0000003933 00000 n 0000005992 00000 n blanch test: Etymology: Fr, blanchir, to become white; L, testum, crucible a test of blood circulation in the fingers or toes. 0000050797 00000 n 0000007956 00000 n 0000001542 00000 n %PDF-1.4 %����