Metabolic pathways for phenacetin involve de-ethylation, N-deacetylation and ring hydroxylation. Inhibitor of cyclooxygenase (COX)-1. May cause liver and [4]. Wu KK, et al.

Chronic: Aspirin and salicylate inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer[3]. It is an esterification reaction. Sorry!, This page is not available for now to bookmark. Aspirin is synthesized by the action of salicylic acid on acetic anhydride.

Topic 18C: Organic synthesis Stable. Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages.

Vane JR, et al. effects include acute renal failure, acute tubular necrosis, cough, Target Organs: Blood, respiratory system, eyes, Appearance: white powder. Aspirin is less effective in inhibiting COX-2 activity. Stable. 0000003325 00000 n Wu KK, et al. Melting point 134 - 136 °C (273 - 277 °F) Boiling point no data available Flash point 250 °C (482 °F) Ignition temperature 500 °C (932 °F) Lower explosion limit no data available Upper explosion limit no data available Water solubility no data available Partition coefficient: log Pow: 1.19 n-octanol/water It is weakly acidic in nature. While in humans much of it is attributable to diet, a substantial part is synthesized endogenously.Aspirin is part of a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs), but differs from most other NSAIDs in the mechanism of action. AT i: Use thin-layer or paper chromatography. ]. irritability. The Preparation of Aspirin, the Recrystallisation of Aspirin and the Melting Point Determination of Aspirin. Freezing/Melting Point:136 - 140 deg C Decomposition Temperature:140 deg C Solubility: 3.3 g/L (20°C) Specific Gravity/Density:1.350 Molecular … pulmonary edema. Mitchell JA, et al. The LibreTexts libraries are Powered by MindTouch® and are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot. Chemsrc provides Aspirin(CAS#:50-78-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an anti-inflammatory compound that inhibits Cox-1. Inhibition of NF-kappa B by sodium salicylate and aspirin. 18 27

It was Bayer’s brand name for the drug. 0000003291 00000 n 18 0 obj<> endobj It must not be taken in very high amounts because in very high concentrations acetylsalicylic acid may cause hallucinations and even death.

Toxic if

It is an analgesic and used to get relief from acute pain. Exhibits antiplatelet and antithrombotic activities. Toxic if swallowed.

In 1897, scientists at Bayer began studying acetylsalicylic acid as a less-irritating replacement for common salicylate medicines. Freezing/Melting Point:136 - 140 deg C Decomposition Temperature:140 deg C Solubility: 3.3 g/L (20°C) Specific Gravity/Density:1.350 Molecular … Unless otherwise noted, LibreTexts content is licensed by CC BY-NC-SA 3.0. All the O atoms have lone pairs of electrons. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, and inflammation.

Pro, Vedantu %PDF-1.4 %���� ;Target: Cox-1Aspirin (USAN), also known as acetylsalicylic acid , is a salicylate drug, often used as ananalgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Proc Natl Acad Sci U S A. At 25 ℃ temperature, its acid dissociation constant is 3.5.

0000011689 00000 n 2003 Jun 15;110(5-6):255-8.

Pro, Vedantu [1]. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc. skin. This is the reason aspirin is also known as acetylsalicylic acid. 0000003369 00000 n Its density is 1.40